Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

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How CRENESSITY Works

CRENESSITY was specifically developed to target the hormone imbalances that drive excess androgens in people with CAH.

In CAH, overproduction of the hormone ACTH leads directly to excess production of androgens. And before CRENESSITY, excess androgens were the reason many people with CAH needed high doses of steroids.

CRENESSITY is the only treatment that targets ACTH overproduction at its source so that lower levels are being made and less ACTH is present throughout the body. As a result of less ACTH being made, the body also produces fewer androgens—which means it’s possible to lower steroid doses, too.

Explore more below to learn how CAH affects the body and how CRENESSITY works.

Explore CAH and CRENESSITY

Explore how CAH affects the body, and how CRENESSITY improves androgen control and allows for lower steroid doses
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Hypothalamus
Pituitary
Adrenal glands

This is the hypothalamus, which is the command center for cortisol production. When the body needs to make more cortisol, the hypothalamus releases a hormone called CRF.

1/4
  • ACTH=adrenocorticotropic hormone;
  • CRF=corticotropin-releasing factor;
  • CRF1=corticotropin-releasing factor type 1 receptor.
Your doctor may lower your steroid dose after you begin taking CRENESSITY
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Next: Starting CRENESSITY

Please see full Important Safety Information

Approved Uses:
CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you:
Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:
Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.