Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

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Starting CRENESSITY

CRENESSITY is a breakthrough treatment for classic CAH: It improves androgen levels to allow for lower steroid doses. Reach out to your doctor to learn more about the benefits of CRENESSITY and how it might be right for you or your child.

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Hear Paul talk about what it was like to start CRENESSITY

Paul shares how CRENESSITY helped change the way he thought about his treatment goals for classic CAH.

Ready to get started with CRENESSITY?

Talk to your doctor today about whether CRENESSITY can help you. There are many ways to reach out to your doctor about CRENESSITY, so pick one that works best for you:

  • In-person appointment
  • Telehealth appointment
  • Email
  • Phone call
  • Patient portal message

How to take CRENESSITY

CRENESSITY is taken by mouth twice daily for steady levels around the clock. Twice daily dosing means androgen levels stay more consistent throughout the day and night.

All adults aged 18 years and older take 100 mg twice daily (200 mg total each day)

CRENESSITY is a capsule taken with morning and evening meals

Ask your doctor if it’s possible to time your steroid doses with your CRENESSITY doses

Take CRENESSITY exactly as your doctor tells you to

Talk to your doctor before stopping CRENESSITY

What if I miss
a dose?

In case of a missed dose, you should take another dose as soon as possible, even if that means taking 2 doses close together. Then resume your regular dosing schedule.

After you start CRENESSITY, your doctor may gradually begin to reduce your steroid dose while ensuring that you still have enough steroid to meet cortisol needs.

Lowering steroid doses while taking CRENESSITY

CRENESSITY lowers or maintains androgens, so your doctor may reduce your steroid dose after you have started CRENESSITY.

  • CRENESSITY does not treat
    cortisol insufficiency, so steroids are still needed
  • Talk to your doctor about a plan to reduce your steroid dose over time and make sure to continue stress dosing when you need it
  • Your lab values and clinical symptoms will help your doctor guide steroid dose reduction
  • Talk to your doctor about what to expect and how you feel as your body adjusts to a lower steroid dose
  • Do not stop or change your steroid dose unless your doctor says to

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Why are lower steroid doses possible?

CRENESSITY lowers or maintains androgen levels, so high steroid doses are no longer the only option to address this treatment goal. Instead, steroid doses can be lowered closer to the dose needed just to replace cortisol.

Is CRENESSITY
right for you?

Reach out to your doctor to find out if CRENESSITY might be right for you. Create a customized guide to help start the conversation—whether at an appointment or via phone, email, or health chart.

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Please see full Important Safety Information

Approved Uses:
CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you:
Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:
Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.